Season Two Edit
Louise is a prisoner who escapes with Five and Eight.
Season Three Edit
Louise led Paula and Runner 5 back to the prison, where they discovered the prison on fire and many of the inmates mind controlled. As they retrieve the research, Louise realizes that all the non-mind-controlled people are prisoners who joined her in an enhanced cognition program.
Shortly thereafter, Louise led Paula, Maxine, Moonchild, and Runner 5 to the Tavington Clinic to cure Maxine's mind control.
Season Four Edit
In "Post War Blues," Jody reveals that Lou did something to make the entire New Canton Permanent Advisory Council cry.
Season Five Edit
Louise accompanies Ed and Molly to the island where Radio Cabel is living